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. 2023 Nov 4;14(3):1345–1361. doi: 10.1016/j.apsb.2023.11.005

Figure 4.

Figure 4

Spatiotemporal targeting behavior and biodistribution of “Gemini nanoimmunoregulators” in vivo. Biofluorescence images of (A) 4T1 tumor-bearing mice, (B) dissected tumors and organs, and (C) semiquantitative analysis of fluorescence signals after intravenous injection of PCy@RM, PCy@RM-M2 and PCy@RM-T7. (D) IF staining results of tumor sections (scale bar = 50 μm) and (E) quantitative analysis of the coincidence of fluorescence signals (Cy5.5 and anti-CD206-FITC) by Image J for groups treated by PCy@RM, PCy@RM-M2 and PCy@RM-T7. Data are presented as mean ± SD (n = 3). ∗P < 0.05 and ∗∗P < 0.01 vs. indicated.