Skip to main content
. 2023 Nov 4;14(3):1009–1029. doi: 10.1016/j.apsb.2023.10.023

Figure 3.

Figure 3

The modulation of histone methylation in liver fibrosis. Mounting studies have shown correlations between histone methylation and liver fibrosis. Methylation at different lysine sites can have antipodal effects on transcription. As “Silencer” proteins, H3K9, H3K27, and H4K20 are involved in gene suppression, whereas H3K4, H3K36, and H3K79 function as “Activator” proteins that promote gene transcription. The “bivalent domains”, formed by H3K4me3, H3K36me3, and H3K79me2/3, as well as the silent markers H3K27me3 and H3K9me2/3, keep gene transcription at a low level, preparing for rapid gene expression with RNA polymerase II loaded. Since chromatin structure is created by DNA wrapping around histones, histone methylation works in conjunction with DNA methylation through EZH2, G9a, and DNMT1.