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. 2023 Nov 4;14(3):1009–1029. doi: 10.1016/j.apsb.2023.10.023

Figure 4.

Figure 4

Histone acetylation in liver fibrosis. This diagram represents the roles of histone acetylation in liver fibrosis. Acetylation of histone is mediated by a dynamic balance between HATs and HDACs. HATs, including P300, KAT2A and KAT8, regulate several fibrosis-related genes including Acta2, Ncf1 and Serpine1 by catalyzing H3K9ac and H3K27ac. HDACs are divided into 2 categories Zn2+-dependent HDACs and NAD+-dependent SIRTs. Several HDACs, including HDAC1, HDAC2, HDAC4, HDAC7, HDAC9 and SIRTs, including SIRT1, SIRT3, SIRT4 and SIRT6, are involved in fibrosis process via targeting TGF-β-Smads pathway, EMT, oxidative stress, cell senescence and HIF/β-catenin pathway.