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. 2023 Nov 4;14(3):1009–1029. doi: 10.1016/j.apsb.2023.10.023

Figure 5.

Figure 5

Scheme diagram of RNA modification in fibrosis. Mounting evidence shows that RNA modification plays a vital role in the fibrosis process. Several miRNAs, including miR-152, miR-29b and miR-125b-5p, promote fibrosis by interacting with DNA methyltransferases and histone deacetylases. LncRNAs, including lncRNA-SCARNA10, lncRNA-HOTAIR, lncRNA-NEAT1, and lncRNA-GAS5, mainly regulate the PRC2 family. Several circRNAs, including hsa_circ_0007874, hsa_circ_0070963, circFBXW4, mmu_circ_34116, circ_PSD3 and circ_PWWP2A inhibited HSC activation via combining with miRNA and thus reversed miRNA-mediated transcription suppression.