Table 1.
Summary of histone modification in liver fibrosis.
| Histone modification | Consequence | Target | Cell type/animal model |
|---|---|---|---|
| Methylation | Inhibits transcription | ||
| H3K27me3 | TGF-β/IGFBP3 | HSC | |
| H3K9me2/3 | TLR4/NF-κB/PPARγ | HSC | |
| H4K20me3 | Bax | HSC | |
| Methylation | Promotes transcription | ||
| H3K4me1/3 | NLRP3/Bivalent domains in PPARγ | Hepatocyte/HSC | |
| H3K36me3 | Bivalent domains with H3K27me3 | HSC | |
| H3K79me3 | Cul4 with Clr4 | Hepatocyte | |
| Acetylation | Promotes transcription | ||
| H3K27ac | CCL2 | LSEC | |
| H3K9ac | Fibronectin and Serpine1 | Cholangiocytes | |