Table 2.

ncRNAs involved in the regulation of liver fibrosis.

ncRNA	Target	Pathway or regulatory mechanism	Output	Ref.
miRNA
miR-542-3p	BMP-7	Decreases BMP-7 expression	Promotes liver fibrosis	116
miR-125b	RhoA	Activates RhoA pathway	Activates HSC	117
miR-199	TGF-β	Activates TGF-β pathway	Promotes liver fibrosis	118
miR-200	TGF-β	Activates TGF-β pathway	Promotes liver fibrosis	118
miR-21	SMAD7	Increases SMAD7 expression	Activates HSC	119
miR-129-5p	Collagen I	Reduces collagen I expression	Promotes liver fibrosis	120
miR-454	Collagen I α-SMA	Reduces collagen I and α-SMA expression	Promotes cirrhosis progression	121
miR-378-3p	Gli3	Reduces Gli3 expression	Inhibits HSC activation	122
miR-222	ICAM-1	Decreases ICAM-1 expression	Promotes HSC proliferation and differentiation	123
miR-185	SREBF1	Increases SREBF1 expression	Promotes liver fibrosis	124
LncRNA
H19	Let-7 ZEB1	Increases expression of let-7 and ZEB1	Promotes cholestatic liver fibrosis	125,126
MEG3	SMO	Decreases SMO expression	Inhibits EMT in liver fibrosis	127
GAS5	miR-222	Competes with miR-222 and	Inhibits HSC activation and proliferation	128
Gm5091	miR-27b/23b/24	Increases TGF-β by sponging to miR-27b/23b/24	Alleviates alcoholic hepatic fibrosis	129
Lnc-LFAR1	Smadd2/3 phosphorylation	Promotes Smadd2/3 phosphorylation	Promotes liver fibrosis	130
NEAT1	miR-122 miR-29b	Increases miR-122 and miR-29b	Promotes liver fibrosis progression	131