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Influences after introducing ‘X’, ‘O’, and ‘N’ into bioactive compounds. Therefore, LSM has been a convenient and powerful strategy for incorporating ‘X’, ‘O’, and ‘N’ into bioactive compounds. This review would explore the role of LSM in the generation of new molecules from the insight of pharmaceutical science. Specifically, late-stage halogenation, oxygenation, and nitrogenation strategies will be expounded along the logic of conversion of functional groups.
