Table 1.
COSMIC [22] missense mutations of the Sam domain from the EphA2 receptor (https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=EPHA2, access date 1 June 2023). Mutations are indicated according to the sequence numbering of UniprotKB [35] entry P29317 for human EphA2. The second column (“Count”) indicates the number of samples exhibiting the corresponding mutation. The third column reports the type of tumours where the mutation has been encountered. Mutations without a reference are associated with the Sanger Institute Cancer Genome Project or taken from the ICGC/TCGA (International Cancer Genome Consortium/The Cancer Genome Atlas).
| EphA2 Mutations |
Count | Tumour Location and Histology |
|---|---|---|
| V904G | 2 | Prostate (Carcinoma; Adenocarcinoma)- Skin (Malignant melanoma) |
| R907C | 1 | Skin; Head neck (Malignant melanoma; Superficial spreading) [38] |
| R907S | 1 | Urinary tract; Bladder (Carcinoma) |
| T908M | 1 | Haematopoietic and lymphoid tissue (Haematopoietic neoplasm; Essential thrombocythaemia) [39] |
| S910F | 1 | Skin (Adnexal tumour; Malignant adnexal tumour; Eccrine porocarcinoma) [40] |
| E911K | 1 | Large intestine; Colon (Carcinoma; Adenocarcinoma) [41] |
| W912C | 1 | Ovary (Carcinoma; Serous carcinoma) [42] |
| E923K | 1 | Cervix (Carcinoma; Squamous cell carcinoma) |
| M926K | 1 | Biliary tract; Bile duct (Carcinoma) |
| A927V | 2 | Central nervous system; Brain (Glioma; Astrocytoma Grade IV; Glioblastoma multiforme) * [43] |
| A928D | 1 | Large intestine (Carcinoma; Adenocarcinoma) [41] |
| G929S | 1 | Large intestine (Carcinoma; Adenocarcinoma) [44] |
| G929C | 1 | Lung; Right upper lobe (Carcinoma; Adenocarcinoma) |
| Y930D | 1 | Lung (Carcinoma; Small cell carcinoma) [45] |
| T940I | 1 | (Malignant melanoma) [38] |
| D942Y | 1 | Endometrium (Carcinoma; Endometrioid carcinoma) |
| D942N | 4 | Prostate (Carcinoma; Adenocarcinoma), Skin (Malignant melanoma), Stomach (Carcinoma; Adenocarcinoma) [46,47] |
| D943N | 1 | Skin (Malignant melanoma) [47] |
| R950W | 1 | Endometrium (Carcinoma; Endometrioid carcinoma) |
| R957C | 2 | Biliary tract; Bile duct (Carcinoma; Adenocarcinoma) [48] Ovary (Carcinoma; Serous carcinoma) [42] |
| L965I | 1 | Stomach (Carcinoma; Intestinal adenocarcinoma) [49] |
* The mutation was encountered in 2 samples from the same tumour location.