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. 2024 Mar 5;13(5):1491. doi: 10.3390/jcm13051491

Figure 2.

Figure 2

The correlation coefficients R Squared between GSK3β and other analytes in CD4+ lymphocytes and monocytes of responders before and after lithium treatment. Legends: (A) is the correlation coefficient R Squared between GSK3β and other analytes in CD4+ lymphocytes, and (B) is the correlation coefficient R Squared between GSK3β and other analytes in lymphocytes. The blue bar is before lithium, and the orange bar is after lithium. Abbreviations: BAX: BAX, BCL2-Associated X Protein; BCL-2: B-cell lymphoma 2; BCL-2 A1: Bcl-2-related protein A1; BDNF: brain-derived neurotrophic factor; Calmodulin: calcium-modulated protein; Fyn: a tyrosine kinase belongs to the Src family of tyrosine kinases including src, fyn, and yes; GSK3β: glycogen synthase kinase 3 beta; HMGB1: High mobility group box 1 protein; iNOS: inducible isoform nitric oxide synthases; IRS2: Insulin receptor substrate 2; MARCKS: myristoylated alanine-rich C-kinase substrate; mTor: mammalian target of rapamycin; NLRP3: NACHT, LRR and PYD domains-containing protein 3; NR3C1: nuclear receptor subfamily 3, group C, member 1; phospho-CREB: phosphorylated cAMP response element-binding protein (Ser133); phospho-Fyn/phospho-Yes: phosphorylated Fyn (Y530)/phosphorylated Yes (Y537); phospho-GSK3α/β: phosphorylated glycogen synthase kinase 3 alpha (Tyr279) beta (Tyr216); phospho- GSK3β: phospho-glycogen synthase kinase 3 beta (Tyr216); phospho-NFkB-P65: phosphorylated nuclear factor NF-kappa-B p65 (Ser536) subunit; PDEB4: cAMP-specific 3′,5′-cyclic phosphodiesterase 4B; PGM1: phosphoglucomutase 1; PKA C-α: protein kinase A catalytic subunit alpha; PKC-θ: protein kinase C theta; PPAR-γ: peroxisome proliferator-activated receptor gamma; Timeless: a protein is necessary of proper functioning of circadian rhythm; TNFAIP3: tumor necrosis factor, alpha-induced protein 3; TPH1: tryptophan hydroxylase 1; XBP1: X-box binding protein 1.