Figure 3.
A protein-protein interaction network of 23 studied proteins related to the 28 analytes in CD4+ lymphocytes that are mapped to the BioGRID database. Note: The color of the nodes represents the magnitude of differences in protein expression levels between lithium responders and non-responders at the baseline as measured with the . A positive value is indicative of a higher level of protein expression in lithium responders relative to non-responders. A negative value is indicative of a lower level of protein expression in lithium responders relative to non-responders. The white nodes are proteins that were not measured in the current study, but they are on the shortest paths between pairs of proteins that are included in the study. PDEB4 was not in the network; phospho-GSK3β, GSK3β, and phospho-GSK3αβ = GSK; fyn and phospho-fyn/yes = FYN. Abbreviations: BAX1: BAX, BCL2-Associated X Protein; BCL2: B-cell lymphoma 2; BCL2A1: Bcl-2-related protein A1; BDNF: Brain-derived neurotrophic factor; CALM1: calcium-modulated protein; CREB1: phosphorylated cAMP response element-binding protein; FYN: a tyrosine kinase belongs to the Src family of tyrosine kinases including src, fyn, and yes; GSK3B: Glycogen synthase kinase 3 beta; HMGB1: High mobility group box 1 protein; IRS2: insulin receptor substrate; MARCKS: myristoylated alanine-rich C-kinase substrate; MTOR: Mammalian target of rapamycin; NLPR3: NACHT, LRR and PYD domains-containing protein 3; NOS1: Inducible isoform nitric oxide synthase; NR3C1: nuclear receptor subfamily 3, group C, member 1; PGM1: Phosphoglucomutase 1; PPARG: Peroxisome proliferator-activated receptor gamma; PRKCA: Protein kinase A catalytic subunit alpha; PRKCQ: protein kinase C theta; NFKB1: nuclear factor NFkB p65 subunit; TIMELESS: a protein is necessary of proper functioning of circadian rhythm; TNFAIP3: tumor necrosis factor, alpha-induced protein 3; TPH1: Tryptophan hydroxylase 1.