Figure 4.

Protein-to-protein subnetworks involved in prolactin, leptin, BDNF, and neurotrophin signaling pathways in CD4⁺ lymphocytes. Note: The color of the nodes represents the magnitude of differences in protein expression levels between lithium non-responders and responders at the baseline as measured with the ${\log }_2(\frac{\mathrm{t}\mathrm{h}\mathrm{e} \mathrm{a}\mathrm{v}\mathrm{e}\mathrm{r}\mathrm{a}\mathrm{g}\mathrm{e} \mathrm{o}\mathrm{f} \mathrm{M}\mathrm{F}\mathrm{R} \mathrm{o}\mathrm{f} \mathrm{R}\mathrm{e}\mathrm{s}\mathrm{p}\mathrm{o}\mathrm{n}\mathrm{d}\mathrm{e}\mathrm{r}\mathrm{s}}{\mathrm{t}\mathrm{h}\mathrm{e} \mathrm{a}\mathrm{v}\mathrm{e}\mathrm{r}\mathrm{a}\mathrm{g}\mathrm{e} \mathrm{o}\mathrm{f} \mathrm{M}\mathrm{F}\mathrm{R} \mathrm{o}\mathrm{f} \mathrm{Non-Responders}})$. A positive value is indicative of a higher level of protein expression in lithium responders relative to non-responders. A negative value is indicative of a lower level of protein expression in lithium responders relative to non-responders. The white nodes are proteins that were not measured in the current study, but they are on the shortest paths between pairs of proteins that are included in the study. Abbreviations: BCL2: B-cell lymphoma 2; BDNF: Brain-derived neurotrophic factor; CALM1: calcium-modulated protein; FYN: a tyrosine kinase belongs to the Src family of tyrosine kinases including src, fyn, and yes; GSK3B: Glycogen synthase kinase 3 beta; IRS2: insulin receptor substrate; MTOR: Mammalian target of rapamycin; NFKB1: nuclear factor NFkB p65 subunit. (A) Neurotrophin signaling pathway; (B) BDNF Signaling Pathway; (C) Leptin Signaling Pathway; (D) Prolactin Signaling Pathway.