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. 2024 Mar 5;13(5):1491. doi: 10.3390/jcm13051491

Table 1.

Results of Pathway Enrichment Analysis and Genes Involved in Pathways Based on the Protein-Protein Networks of the 23 Proteins.

Pathway Genes p-Value
Prolactin Signaling Pathway FYN; GSK3β; MTOR; NFKB; IRS2; ITGB1; IRS1; SHC1; STAT3; IRS2; PTPN11; PIK3R1; YWHAZ; VAV1; ERBB2; GRB2; PTPN6; RAF1 1 × 1026
Leptin signaling pathway FYN; GSK3β; NFKB; MTOR; IRS1; SHC1; STAT3; PTPN11; PIK3R1; ESR1; SP1; ERBB2; GRB2; RAF1 1 × 1021
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway GSK3β; IRS2; MTOR; NFKB; FYN; BDNF; NTRK2; NCF1; IRS1; SHC1; PRKCD; STAT3; PTPN11; PIK3R1; SYN1; CTNNB1; GRB2; MAPT; RAF1 1 × 1025
Neurotrophin signaling pathway CALM1; IRS2; BCL2; BDNF; GSK3β; NFKB; YWHAE; NTRK2; IRS1; SHC1; PRKCD; PTPN11; PIK3R1; YWHAZ; YWHAQ; ABL1; GRB2; RAF1; TP53; YWHAH 1 × 1028

Note: The bold genes are implicated in the current study. Abbreviations: BCL2: B-cell lymphoma 2; BDNF: Brain-derived neurotrophic factor. CALM1: calcium-modulated protein. FYN: a tyrosine kinase belongs to the Src family of tyrosine kinases, including src, fyn, and yes; GSK3β: Glycogen synthase kinase 3 beta: IRS2: insulin receptor substrate; MTOR: Mammalian target of rapamycin; NFKB: nuclear factor NF-kappa-B p65 subunit.