Table 2.
Baseline myogenic tone, EiP50, and maximal myogenic constriction of uterine arteries from nonpregnant WT and Rgs5−/− mice in the presence of L-NAME + dopamine (10 μm) or L-NAME + Db-cAMP (10 μm).
| Intraluminal Ca2+-free HEPES + L-NAME + dopamine (10 μm) | Intraluminal Ca2+-free HEPES + L-NAME + Db-cAMP (10 μm) | |||||
|---|---|---|---|---|---|---|
| WT (n = 4) | Rgs5−/− (n = 4) | P-value | WT (n = 5) | Rgs5−/− (n = 3) | P-value | |
| Basal myogenic tone @ 60 mm Hg (%) | 51 ± 9 | 32 ± 12 | 0.1238 | 7 ± 3 | 4 ± 3 | 0.2341 |
| Half-maximal effective intraluminal pressure (EiP50) (mm Hg) | 46 ± 17 | 71 ± 2 | 0.1810 | 100 ± 8 | 115 ± 12 | 0.2107 |
| Maximal myogenic constriction, Emax (%) | 69 ± 6 | 60 ± 4 | 0.1567 | 52 ± 5 | 48 ± 2 | 0.2280 |
Values are mean ± SEM.