Table 4.
Follow-up outcomes
| Variable | Total (n=964) | Grade C (n=595) | Grade D (n=369) | P value | |
| Interval oesophagogastroduodenoscopy (OGD1) to OGD2 (weeks), median (IQR) | 10.1 (7.8–20.4) | 10.2 (7.6–21.3) | 10.1 (7.4–19.9) | 0.800 | |
| Biopsies taken at OGD2, % (N) | 34.3 (132/385) | 31.8 (75/236) | 38.3 (57/149) | 0.192 | |
| Macroscopic appearance OGD2, % (N) | Completely healed | 66.2 (255/385) | 69.9 (165/236) | 60.4 (90/149) | 0.055 |
| Grade A | 6.2 (24/385) | 7.2 (17/236) | 4.7 (7/149) | 0.322 | |
| Grade B | 4.9 (19/385) | 5.1 (12/236) | 4.7 (7/149) | 0.865 | |
| Grade C | 9.4 (36/385) | 7.6 (18/236) | 12.1 (18/149) | 0.144 | |
| Grade D | 3.1 (12/385) | 2.1 (5/236) | 4.7 (7/149) | 0.156 | |
| Grade not specified | 10.1 (39/385) | 8.1 (19/236) | 13.4 (20/149) | 0.089 | |
| New stricture OGD2, % (N) | 2.3 (9/385) | 1.7 (4/236) | 3.4 (5/149) | 0.294 | |
| New cancer OGD2, % (N) | 0.3 (1/385) | 0.4 (1/236) | 0 (0/149) | 0.426 | |
| New atypia OGD2, % (N) | 1.8 (7/385) | 2.1 (5/236) | 1.3 (2/149) | 0.579 | |
| New dysplasia OGD2, % (N) | 0.5 (2/385) | 0.4 (1//236) | 0.7 (1/149) | 0.742 | |
| New IM OGD2, % (N) | 7.0 (27/385) | 4.7 (11/236) | 10.7 (16/149) | 0.023* | |
| New combined Barrett’s appearances and IM on OGD2, % (N) | 10.1 (39/385) | 6.8 (16/236) | 15.4 (23/149) | 0.006* | |
| New Barrett’s appearances on OGD2, % (N) | 3.1 (12/385) | 2.1 (5/236) | 4.7 (7/149) | 0.156 | |
| Prague classification C OGD2 (cm), median (IQR) | 2.0 (0.8–3.3) (n=36) | 2.0 (1.0–3.8) (n=18) | 1.0 (0.3–3.0) (n=18) | 0.618 | |
| Prague classification M OGD2 (cm), median (IQR) | 3.0 (2.0–5.0) (n=36) | 3.0 (2.0–4.8) (n=18) | 3.0 (2.3–5.0) (n=18) | 0.521 | |
| Notes follow-up time (months), median (IQR) | 76.0 (72.0–83.0) | 76.0 (73.0–85.0) | 75.0 (71.0–80.0) | <0.001* | |
| Deceased at time of notes follow-up, % (N) | 32.1 (309) | 26.1 (155) | 41.7 (154) | <0.001* | |
| Deceased within 6 months of OGD1, % (N) | 9.4 (91) | 6.9 (41) | 13.6 (50) | 0.001* | |
| Deceased within 12 months of OGD1, % (N) | 11.8 (114) | 8.2 (49) | 17.6 (65) | <0.001* | |
| Time OGD1 to date of death (months), median (IQR) | 24.0 (5.0–50.0) | 27.0 (6.0–52.0) | 18.5 (3.5–47.5) | 0.086 | |
*Statistically significant result (p<0.05). The Mann-Whitney U test compared continuous variables; the χ2 test compared categorical variables.
IM, intestinal metaplasia; OGD1, index endoscopic procedure; OGD2, repeat endoscopic procedure.