TABLE 1.
Characteristics of the CD4C/HIVWT founders
| Founder | Sexa | Clinical disease | No. of Tg mice/total no. of mice born (%) | Mosa- icism | N1 Tg pups surviving >15 days |
|---|---|---|---|---|---|
| 15564 | M | No | 3/69 (4.3) | Yes | Nob |
| 17001 | M | No | 7/212 (3.3) | Yes | Yesc |
| 17018 | M | Yes (sudden death) | 13/32 (40) | No | Yesc |
| 17027 | M | No | 0/98 (0) | Yes | NAd |
| 17086 | F | Yes (intestinal lymphoma) | 3/20 (15) | Yes | Yesc |
a
M, male; F, female.
b
Tg animals were found dead at a very early age (<15 days), and the assessment of their pathology (if any) could not be made.
c
These mice survived and later developed severe disease, as described in the text.
d
NA, not applicable.