TABLE 2.

Incidence of disease in CD4C/HIV^WT Tg mice

Pathology observeda	No. with trait/total no. studiedb
	15564		17001		17018		17086		Totale
	+ (15 ± 1.7)c	−d	+ (30.3 ± 5)	−	+ (25.2 ± 7)	−	+ (21)	−	+	−
Macroscopic
Small body size, ruffled fur, and hypoactivity	3/3f	0/23	7/7	0/52	13/13	0/32	2/2	0/20	25/25	0/127
Diarrhea	0/1	0/23	3/7	0/52	2/4	0/32	1/2	0/20	6/14	0/127
Edema	0/1		2/7	0/7	2/4	0/4	1/2	0/2	5/14	0/13
Low body wt	1/1		7/7	0/7	4/4	0/4	2/2	0/2	14/14	0/13
Small or absent thymus	1/1		7/7	0/7	4/4	0/4	2/2	0/2	14/14	0/13
Small or absent lymph nodes	1/1		7/7	0/7	3/4	0/4	1/2	0/2	12/14	0/13
Small pale spleen	1/1		7/7	0/7	3/4	0/4	1/2	0/2	12/14	0/13
Small and/or mottled kidney	1/1		6/7	0/7	2/4	0/4	2/2	0/2	11/14	0/13
Microscopic
Thymus (hypocellularityg)			1/2	0/6	4/4	0/4	1/2	0/2	6/8	0/12
Spleen (hypocellularityg)			4/5	1/6	2–3/3	0/4	1/2	0/2	7/10	1/12
Lymph node (hypocellularityg)			1/1	0/2	4/4	NAh	0/1	0/1	5/6	0/3
Kidney (tubular interstitial nephritis)			6/7	0/7	2–3/3	0/3	1–2/2	0/1	9/12	0/11
Lung (interstitial pneumonitis)			1/6	0/5	3/4	0/4	2/2	0/1	6/12	0/10

^aSee the text for a detailed description of the disease. 

^bThe mice studied include the Tg founder itself as well as Tg (+) and non-Tg (−) offspring derived from each founder (F15564, F17001, F17018, and F17086). 

^cNumbers in parentheses are the mean age in days (± standard deviation) at which N1 animals died of disease or were sacrificed due to severe illness. A total of 3, 7, 13, and 2 mice from founders F15564, F17001, F17018, and F17086, respectively, were assessed. 

^dFor all Tg lines studied, non-Tg mice (−) were littermates of Tg mice kept in the same cages and sacrificed on the same day as the Tg mice. Equal number of Tg and non-Tg mice were autopsied. 

^eTotal numbers of animals assessed in all lines. 

^fHypoactivity was not assessed for these three mice. 

^gDisorganized architecture accompanied hypocellularity in most organs assessed. 

^hNA, not assessed.