TABLE 3.
Characteristics of CD4C/HIVWT chimeric mice
| ES clone inoculated | No. with the following trait/total no.
|
||||
|---|---|---|---|---|---|
| Coat color chimerism | Clinical disease
|
Pathological lesions in chimeric mice | Transgene expression | ||
| Chimeric mice | Nonchimeric mice | ||||
| J1-1838-2 | 12/35 | 1/12 | 0/23 | 0/8 | 1/8 |
| J1-1838-5 | 15/21 | 5/15 | 0/6 | 4/13a | 5/13b |
a
The four chimeric mice with pathological lesions had no. 20882, 20883, 20886, and 20887. See the text for a description.
b
The mice which showed the highest number of in situ positive cells (no. 20886 and 20887) also demonstrated the highest degree of histopathology.