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. Author manuscript; available in PMC: 2024 Mar 13.
Published in final edited form as: Lab Anim (NY). 2023 Jun 29;52(7):149–168. doi: 10.1038/s41684-023-01196-z

Figure 2.

Figure 2.

HLA Matching of Allogeneic Thymus and Umbilical Cord Blood HSPCs. Five umbilical cord blood (UCB) donors and five neonatal thymus donors were HLA typed at 11 loci using the LinkSeq Real-Time PCR typing method. When making the NeoThy humanized mouse using allogeneic UCB and thymus, we recommend matching at a minimum of one HLA-Class I allele, and one HLA-Class II allele. For example, UCB donor WB107 is a match to thymus donor PED16 at HLA-A2 and HLA-DPB4 (genes with common alleles shaded in grey), and UCB donor WB102 matches thymus donor PED18 at multiple loci (shaded in yellow). Downstream transplantation studies should consider UCB:Thymus matches together in conjunction with matches/mismatches in HLA type of transplanted tissues.