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. Author manuscript; available in PMC: 2024 Apr 12.
Published in final edited form as: Cell Host Microbe. 2023 Mar 29;31(4):554–570.e7. doi: 10.1016/j.chom.2023.03.006

Figure 5. Increased susceptibility of PedsCom gnotobiotic mice to Salmonella infection.

Figure 5.

A. Percent survival of adult PedsCom, CMCom and GF mice infected with Salmonella enterica s. Typhimurium SL1344. Adult mice were 10–17 weeks of age. Germfree (N = 9), PedsCom (N = 9), and CMCom (N = 10). Log-rank Mantel-Cox test *p<0.05. Data from two independent experiments. B. Salmonella burden 1 day post infection in feces [Germfree (N = 3), PedsCom (N = 9), and CMCom (N = 7)], Peyer’s patches and spleen 3 days post infection [Germfree (N = 2), PedsCom and CMCom (N = 5)]. CFU per gram feces or indicated tissue. GF = Germfree, CC = CMCom, PC = PedsCom. C. Pathologic features of CMCom and PedsCom large intestine tissue 3 days post Salmonella infection. Arrows indicate minor inflammatory infiltrates within the mucosa and arrowheads indicate crypt abscesses. (H&E staining, 200x magnification, scale bar: 100 μm). D and E. Pathological scores of small and large intestine tissue 3 days post Salmonella infection in PedsCom and CMCom mice (N = 5 per tissue). Median values shown. Mann-Whitney-Wilcoxon test *p<0.05, **p<0.01, ***p<0.001.