Table 4.

The minimum sample size required per RCT arm to observe a considerable reduction in functional decline

	FAQ	ECog	CDR-SB-F
Braak I–II	3951	6925	4020
Braak III–IV	1170	565	8204
Braak V–VI	78	265	288

The table contains the calculation of the minimum sample required for a 25% slowing in functional decline to be observed, considering the baseline PET-based Braak stage of participants. CDR-SB-F, functional Clinical Dementia Rating sum of boxes; ECog, Everyday Cognition; FAQ, Functional Activities Questionnaire; RCT, randomized controlled trial.