Fig. 2. Ribbon diagram representations of the (A) 2MP-α₃C (RCSB PDB ID 2LXY) and (B) 4MP-α₃C (8VSW) solution NMR structures. The average SASA of 2MP-C₃₂ and 4MP-C₃₂ are 3.5 ± 0.7% and 8.7 ± 2.4%, respectively, across the 32-member structural ensembles that represent these proteins in solution. The zoom-in panels display the ensemble average SASA of the heavy atoms in the MP-C₃₂ residues. Top panel, SASA of 2MP-C₃₂: aromatic C₁ carbon and phenol oxygen, ≤∼2%; all other heavy atoms, ≤∼5%. Bottom panel, SASA of 4MP-C₃₂: aromatic C₁ carbon and phenol oxygen, 30–40%; all remaining aromatic carbons, 15–24%; S–S bridge and C₃₂ atoms, ≤∼4%. The percent SASA given for the heavy atoms are relative to the total area of each individual atom.