Fig. 2.

PPEIP genes with hypermethylated promoters are involved in several cancer-associated cellular pathways and mechanisms. (A) Biocarta pathway analysis for pathway gene enrichment. The shade of green presents the significance of the specific gene-set or term. (B) Enrichment of transcription factor (TF) binding associated with hyper-methylated PPEIP genes from ChIP-seq experiments of > 300 TFs from the ENCODE project. Bright green presents higher number of genes. C-D. Orthogonal cellular pathway analyses from two independent resources; Kyoto Encyclopedia of Genes and Genomes (KEGG) and Curated wiki. For Figures A-D, the brighter the tone of green, the more significant the term is. In all network images (B-D), the grey lines represent gene content similarity