Table 2.
Variant allele frequencies as per the called SNVs/indels
| Chr | Start | End | Ref | Alt | Func refGene |
Gene refGene |
MCB | MCB (expansion culture) | hiPSC-CM | hiPSC-CM patch | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cov | alt_ ratio |
cov | alt_ ratio |
cov | alt_ratio | cov | alt_ ratio |
|||||||
| chr3 | 78,708,860 | 78,708,860 | T | A | exonic | ROBO1 | 59 | 64.4% | 61 | 54.1% | 39 | 56.4% | 60 | 56.7% |
| chr5 | 83,356,228 | 83,356,228 | G | A | exonic | EDIL3 | 96 | 45.8% | 98 | 37.8% | 58 | 55.2% | 82 | 46.3% |
| chr5 | 175,837,271 | 175,837,271 | C | G | exonic | CLTB | 81 | 46.9% | 77 | 46.8% | 58 | 39.7% | 68 | 41.2% |
| chr7 | 100,175,865 | 100,175,865 | A | G | exonic | LRCH4 | 65 | 46.2% | 97 | 45.4% | 63 | 58.7% | 87 | 39.1% |
| chr8 | 4,851,937 | 4,851,937 | A | T | exonic | CSMD1 | 52 | 53.8% | 34 | 41.2% | 59 | 47.5% | 50 | 50.0% |
| chr9 | 103,340,555 | 103,340,555 | G | A | exonic | MURC | 66 | 54.5% | 93 | 48.4% | 75 | 50.7% | 78 | 50.0% |
| chr11 | 48,286,119 | 48,286,119 | C | T | exonic | OR4X1 | 82 | 50.0% | 93 | 54.8% | 68 | 55.9% | 76 | 57.9% |
| chr20 | 1,300,304 | 1,300,304 | C | T | splicing | SDCBP2 | 66 | 43.9% | 63 | 46.0% | 49 | 46.9% | 48 | 43.8% |
| chr12 | 6,675,434 | 6,675,434 | C | T | exonic | NOP2 | 83 | 21.7% | 77 | 53.2% | 53 | 56.6% | 65 | 56.9% |
| chr12 | 50,746,672 | 50,746,672 | A | G | exonic | FAM186A | 98 | 30.6% | 83 | 21.7% | 58 | 17.2% | 91 | 29.7% |
| chr15 | 42,511,798 | 42,511,798 | T | A | exonic | TMEM87A | 146 | 24.0% | 145 | 1.4% | 67 | 0.0% | 110 | 0.9% |
| chr18 | 14,852,387 | 14,852,387 | G | T | exonic | ANKRD30B | 87 | 25.3% | 100 | 2.0% | 68 | 1.5% | 116 | 2.6% |
| chr1 | 201,180,485 | 201,180,485 | A | G | exonic | IGFN1 | 119 | 33.6% | 139 | 26.6% | 96 | 30.2% | 117 | 40.2% |
| chr11 | 65,480,401 | 65,480,401 | C | T | exonic | KAT5 | 61 | 24.6% | 62 | 0.0% | 59 | 1.7% | 49 | 0.0% |
| chr8 | 23,115,566 | 23,115,566 | G | A | exonic | CHMP7 | 87 | 12.6% | 80 | 3.8% | 63 | 1.6% | 63 | 0.0% |
| chr10 | 114,182,146 | 114,182,146 | G | T | exonic | ACSL5 | 93 | 1.1% | 84 | 51.2% | 53 | 47.2% | 71 | 47.9% |
| chr17 | 33,749,201 | 33,749,203 | TCT | - | exonic | SLFN12 | 105 | 0.0% | 100 | 44.0% | 70 | 37.1% | 67 | 44.8% |
| chr1 | 152,883,009 | 152,883,009 | T | C | exonic | IVL | 49 | 12.2% | 53 | 15.1% | 72 | 11.1% | 55 | 9.1% |
| chr16 | 15,711,240 | 15,711,240 | G | A | exonic | KIAA0430 | 85 | 1.2% | 102 | 12.7% | 64 | 10.9% | 68 | 7.4% |
| chr12 | 50,746,414 | 50,746,414 | T | G | exonic | FAM186A | 97 | 28.9% | 82 | 29.3% | 58 | 25.9% | 82 | 36.6% |
| chr1 | 186,276,394 | 186,276,394 | T | G | exonic | PRG4 | 46 | 17.4% | 34 | 11.8% | 52 | 28.8% | 55 | 23.6% |
| chr3 | 195,512,734 | 195,512,734 | T | G | exonic | MUC4 | 188 | 13.8% | 175 | 13.1% | 106 | 22.6% | 151 | 15.9% |
| chr1 | 238,048,745 | 238,048,745 | G | T | exonic | ZP4 | 92 | 0.0% | 68 | 4.4% | 51 | 5.9% | 77 | 3.9% |
alt_ratio, alternative ratio; Chr, chromosome; cov, depth of coverage; hiPSC-CM, human induced pluripotent stem cell-derived cardiomyocyte; Indels, insertions/deletions; MCB, master cell bank; SNV, single-nucleotide variant