Table 2.
Top 10 selected enriched pathways of interest in fEVs compared to aEVs in the gene ontology (GO) analysis (P-adj < 0.05)
| No | GO Accession ID | GO Name | Gene Symbols | FDR P.adjust |
|---|---|---|---|---|
| 1 | GO:0030199 | Collagen fibril organization |
COL5A2/PXDN/COL3A1/ COL1A1/ANXA2/EMILIN1 |
5.1E-07 |
| 2 | GO:0006457 | Protein folding |
HSPA8/HSPA5/HSP90AB1/HSP90AA1/QSOX1/PPIA/ PDIA3/HSPA1A |
5.2E-07 |
| 3 | GO:0071560 | Cellular response to transforming growth factor beta stimulus |
DKK3/COL3A1/COL1A1/ HSPA5/HSP90AB1/HSPA1A/EMILIN1 |
0.2E-4 |
| 4 | GO:0071559 | Response to transforming growth factor beta |
DKK3/COL3A1/COL1A1/ HSPA5/HSP90AB1/HSPA1A/EMILIN1 |
0.2E-4 |
| 5 | GO:0007179 | Transforming growth factor beta receptor signalling pathway |
DKK3/COL3A1/HSPA5/ HSP90AB1/HSPA1A/ EMILIN1 |
0.5E-4 |
| 6 | GO:0017015 | Regulation of transforming growth factor beta receptor signalling pathway |
DKK3/HSPA5/HSP90AB1/ HSPA1A/EMILIN1 |
0.9E-4 |
| 7 | GO:1,903,844 | Regulation of cellular response to transforming growth factor beta stimulus |
DKK3/HSPA5/HSP90AB1/ HSPA1A/EMILIN1 |
0.9E-4 |
| 8 | GO:0006757 | ATP generation from ADP |
GAPDH/PKM/ENO1/ ALDOA |
0.3E-3 |
| 9 | GO:0032388 | Positive regulation of intracellular transport |
MSN/YWHAE/HSP90AB1/ CD81/ANXA2 |
0.4E-3 |
| 10 | GO:0035967 | Cellular response to topologically incorrect protein |
HSPA8/VCP/HSPA5/ HSPA1A |
0.4E-3 |