TABLE 4.

Characteristics of the three patients with ruptured varices.

Case	Age (years)	Sex	Etiology	Child‐Pugh class, score	Modified ALBI grade	Splenomegaly	Portosystemic collateral vessels	History of treatment for varices prior to HCC being noted	EV	GV	Treatment for varices for start of Atezo + Beva	Treatment for varices while receiving Atezo + Beva	Rupture site	Cycle of Atezo + Beva administered before varices ruptured
1	62	Male	HBV	B, 7	2b	+	−	EVL + EIS	F1RC1	−	EVL	EVL	EV	16
2	65	Male	Alcohol	A, 6	2a	+	+	EVL	F1RC0	F1RC0	−	−	GV	8
3	65	Male	HCV	A, 5	2a	+	+	EVL + EIS	F1RC0	−	−	−	EV	17

Abbreviations: ALBI, albumin–bilirubin index; Atezo + Beva, atezolizumab plus bevacizumab combination therapy; EIS, endoscopic injection sclerotherapy; EV, esophageal varices; EVL, endoscopic variceal ligation; F, form; GV, gastric varices; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; RC, red color sign.