Table 2.
Summary information for simulated populations
| Simulation | A | B | C | D | E | F | G | H | I | J | K |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Proportion of true (TEi) influencing expect treatment effect (ETEi) – (Ki)a | % of Treatment Choice Variation Explained by (TEi)b | Fully Observed Heterogeneity: % of Patients Overlappedc | Partially Observed Heterogeneity: % of Patients Overlappedd | Average True Absolute Treatment Effect (TEi) Within Subset (Percentage of Patients) | Parametric Linear Probability Model Estimate (ATT) | ||||||
| Full Population | Overlapped with Fully Observed Heterogeneity | Non-Overlapped with Fully Observed Heterogeneity | |||||||||
| Treated | Untreated | Treated | Untreated | Treated | Untreated | ||||||
| 1 | 0 | .0006 | 100 | 100 | .250 (49.8) | .251 (50.2) | .250 (49.8) | .251 (50.2) | .249 | ||
| 2 | .10 | .18 | 100 | 100 | .256 (49.8) | .246 (50.2) | .256 (49.8) | .246 (50.2) | .255 | ||
| 3 | .20 | 1.4 | 100 | 100 | .264 (50.0) | .237 (50.0) | .264 (50.0) | .237 (50.0) | .267 | ||
| 4 | .30 | 5.3 | 100 | 100 | .277 (50.1) | .224 (49.9) | .277 (50.1) | .224 (49.9) | .276 | ||
| 5 | .40 | 11.9 | 100 | 100 | .290 (50.1) | .212 (49.9) | .290 (50.1) | .212 (49.9) | .292 | ||
| 6 | .50 | 20.1 | 100 | 100 | .301 (50.2) | .200 (49.8) | .301 (50.2) | .200 (49.8) | .300 | ||
| 7 | .60 | 27.8 | 97.0 | 100 | .310 (50.2) | .191 (49.8) | .304 (48.7) | .196 (48.3) | .500 (1.5) | .001 (1.5) | .307 |
| 8 | .70 | 34.5 | 90.7 | 100 | .317 (50.3) | .184 (49.7) | .300 (45.5) | .200 (45.2) | .475 (4.8) | .025 (4.5) | .316 |
| 9 | .80 | 39.8 | 84.5 | 100 | .322 (50.2) | .179 (49.8) | .297 (42.3) | .203 (42.1) | .457 (7.9) | .044 (7.6) | .321 |
| 10 | .90 | 44.3 | 78.3 | 100 | .326 (50.2) | .175 (49.8) | .293 (39.2) | .207 (39.1) | .442 (11.0) | .059 (10.7) | .321 |
| 11 | 1.00 | 48.0 | 68.8 | 100 | .329 (50.3) | .172 (49.7) | .285 (34.4) | .214 (34.4) | .423 (15.8) | .077 (15.3) | .329 |
aThe proportion of patient-specific TEi knowledge used by decision makers in simulation “j” in developing the expected treatment effect for patient “i” that is distinct from the population average treatment effect based on the equation ETEi = Kj * (TEi(X1i,X2i,X3i,X4i,X5i,X6i)—.25) + .25. The population average treatment effect is .25 in all simulations
bThe percentage of treatment choice variation explained by TEi using a linear probability model of treatment choice Ti on true TEi using SAS PROC REG procedure with the SCORR1 option
cPercentage of patients in sample with treatment propensity score greater than .05 and less than .95 when all six patient factors are fully specified in the propensity score equation
dPercentage of patients in sample with treatment propensity score greater than .05 and less than .95 when only X1i, X2i, X3i, X4i factors are specified in the propensity score equation