Fig. 5.

Plasmatic extracellular vesicles as a reference in the neat plasma search. A Distribution of identified protein groups across 33 neat plasma with and without EV boost search. For each analysis, different filters were applied in DIA-NN 1.8.2 beta27, particularly when EV boost search was applied in order to assess confidence in identification. B Density plots of plasma proteins identified in at least 1 neat plasma sample (3035 over 5030 PGs in total matrix) when EV boost search is applied and analyzed with DIA-NN 1.8.2 beta27. C In grey are represented the distribution of the plasma proteins found without EV boost and in red are represented the distribution of the newly identified proteins (1841) thanks to EV boost