Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of the proposed role of TIGAR in EC metabolism and angiogenesis. Loss of TIGAR in EC increases endothelial glucose metabolism which improves angiogenesis and coronary microvascular function and eventually blunts pressure overload-induced LV hypertrophy and heart failure. CFR, coronary flow reserve; EC, endothelial cell; KO, knockout; LV, left ventricular; TIGAR, TP53-induced glycolysis and apoptosis regulator
