Table 3.
TLR2 gene (−196 to −174) del polymorphism and TLR1 743 A > G genotype and allele frequencies among PTB and MDR, MDR and XDR, PTB and XDR.
| PTB (N = 101) | MDR (N = 104) | XDR (N = 48) | Chi, (DF) & p value | OR (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|---|
| PTB vs. MDR | MDR vs. XDR | PTB vs. XDR | PTB vs. MDR | MDR vs. XDR | PTB vs. XDR | ||||
| TLR2 (−196 to −174) del polymorphism | |||||||||
| I/I | 74 (0.73) | 73 (0.70) | 16 (0.33) | 1.90, (2) & 0.38 | 20.27 (2) & 0.0001 | 21.70 (2) & 0.0001 | |||
| I/D | 23 (0.23) | 22 (0.21) | 27 (0.57) | ||||||
| D/D | 4 (0.04) | 9 (0.09) | 5 (0.10) | ||||||
| I | 171 (0.85) | 168 (0.81) | 59 (0.61) | 1.07 (1) & 0.29 | 12.95 (1) & 0.0001 | 19.87 (1) & 0.0001 | 1.31 (0.78–2.19) | 2.63 (1.54–4.49) | 3.45 (1.97–6.04) |
| D | 31 (0.15) | 40 (0.19) | 37 (0.38) | ||||||
| Dominant | |||||||||
| II | 74 (0.73) | 73 (0.70) | 16 (0.34) | 0.23 (1) & 0.62 | 18.38 (1) & 0.0001 | 21.69 (1) & 0.0001 | 1.16 (0.63–2.13) | 4.70 (2.27–9.74) | 5.48 (2.61–11.47) |
| ID+DD | 27 (0.27) | 31 (0.29) | 32 (0.66) | ||||||
| Over-dominant | |||||||||
| II + DD | 78 (0.77) | 82 (0.78) | 21 (0.44) | 0.07 (1) & 0.78 | 18.51 (1) & 0.0001 | 16.35 (1) & 0.0001 | 0.90 (0.47–1.75) | 4.79 (2.29–9.99) | 4.36 (2.09–9.05) |
| ID | 23 (0.23) | 22 (0.21) | 27 (0.56) | ||||||
| Recessive | |||||||||
| ID+II | 97 (0.96) | 95 (0.91) | 43 (0.90) | 1.90 (1) & 0.168 | 0.122 & 0.72 | 2.38 (1) & 0.12 | 2.29 (0.72–7.26) | 1.22 (0.40–3.72) | 2.18 (0.77–10.2) |
| DD | 4 (0.04) | 9 (0.09) | 5 (0.10) | ||||||
| TLR1 743 A > G | |||||||||
| A/A | 29 (0.29) | 31 (0.29) | 15 (0.31) | 0.11 (2) & 0.94 | 0.034 (2) & 0.98 | 0.18 (2) & 0.91 | |||
| A/G | 50 (0.49) | 49 (0.48) | 22 (0.46) | ||||||
| G/G | 22 (0.22) | 24 (0.23) | 11 (0.23) | ||||||
| A | 108 (0.54) | 111 (0.53) | 52 (0.54) | 0.0004 (1) & 0.98 | 0.017 (1) & 0.89 | 0.01 (1) & 0.91 | 1.00 (0.68–1.47) | 0.96 (0.59–1.57) | 0.97 (0.59–1.5 8) |
| G | 94 (0.46) | 97 (0.47) | 44 (0.46) | ||||||
| Dominant | |||||||||
| AA | 29 (0.28) | 31 (0.30) | 15 (0.32) | 0.02 (1) & 0.86 | 0.032 & 0.85 | 0.106 (1) & 0.75 | 0.94 (0.52–1.75) | 0.93 (0.44–1.94) | 0.88 (0.42–1.85) |
| AG + GG | 72 (0.72) | 73 (0.70) | 33 (0.68) | ||||||
| Over dominant | |||||||||
| AA+GG | 51 (0.51) | 55 (0.52) | 26 (0.54) | 0.11 (1) & 0.73 | 0.021 (1) & 0.88 | 0.17 (1) & 0.67 | 0.90 (0.52–1.56) | 0.94 (0.48–1.87) | 0.86 (0.43–1.71) |
| AG | 50 (0.49) | 49 (0.48) | 22 (0.46) | ||||||
| Recessive | |||||||||
| AG + AA | 79 (0.78) | 80 (0.77) | 37 (0.77) | 0.04 (1) & 0.82 | 0.0005 (1) & 0.98 | 0.02 (1) & 0.87 | 1.07 (0.56–2.06) | 0.99 (0.44–2.21) | 1.06 (0.47–2.40) |
| GG | 22 (0.22) | 24 (0.23) | 11 (0.23) | ||||||