Table 4.
TLR2 gene (−196 to −174) del polymorphism and TLR1 743 A> G genotype and allele frequencies between healthy controls and PTB, healthy controls and MDR, and healthy controls and XDR patients.
| Healthy (N = 130) | PTB (N = 101) | MDR (N = 104) | XDR (N = 48) | Chi (DF) & p value | OR (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Healthy vs. PTB | Healthy vs. MDR | Healthy vs. XDR | Healthy vs. PTB | Healthy vs. MDR | Healthy vs. XDR | |||||
| TLR2 (−196 to −174) del polymorphism | ||||||||||
| I/I | 92 (0.71) | 74 (0.73) | 73 (0.70) | 16 (0.33) | 1.39 (2) & 0.49 | 0.07 (2) & 0.96 | 22.07 (2) & 0.0001 | 0.88 (0.49–1.57) | 1.02 (0.58–1.80) | 4.84 (2.39–9.77) |
| I/D | 28 (0.21) | 23 (0.23) | 22 (0.21) | 27 (0.57) | ||||||
| D/D | 10 (0.08) | 4 (0.04) | 9 (0.09) | 5 (0.10) | ||||||
| I | 212 (0.82) | 171 (0.85) | 168 (0.81) | 59 (0.61) | 0.77 (1) & 0.37 | 0.04 (1) & 0.83 | 15.55 (1) & 0.0001 | 0.80 (0.48–1.30) | 1.05 (0.66–1.67) | 2.76 (1.65–4.63) |
| D | 48 (0.18) | 31 (0.15) | 40 (0.19) | 37 (0.38) | ||||||
| Dominant | ||||||||||
| II | 92 (0.71) | 74 (0.73) | 73 (0.70) | 16 (0.34) | 0.17 (1) & 0.67 | 0.009 (1) & 0.92 | 20.59 (1) & 0.0001 | 0.88 (0.49–1.57) | 1.02 (0.58–1.80) | 4.84 (2.39–9.77) |
| ID+DD | 38 (0.29) | 27 (0.27) | 31 (0.29) | 32 (0.66) | ||||||
| Over-dominant | ||||||||||
| II + DD | 102 (0.78) | 78 (0.77) | 82 (0.78) | 21 (0.44) | 0.05 (1) & 0.82 | 0.005 (1) & 0.94 | 19.78 (1) & 0.0001 | 1.04 (0.57–1.99) | 0.97 (0.52–1.82) | 4.68 (2.32–9.45) |
| ID | 28 (0.22) | 23 (0.23) | 22 (0.21) | 27 (0.56) | ||||||
| Recessive | ||||||||||
| ID+II | 120 (0.92) | 97 (0.96) | 95 (0.91) | 43 (0.89) | 1.39 (1) & 0.23 | 0.07 (1) & 0.78 | 0.33 (1) & 0.56 | 0.49 (0.15–1.54) | 1.13 (0.45–2.83) | 1.39 (0.47–4.14) |
| DD | 10 (0.08) | 4 (0.04) | 9 (0.09) | 5 (0.10) | ||||||
| TLR1 743 A > G | ||||||||||
| A/A | 20 (0.15) | 29 (0.29) | 31 (0.29) | 15 (0.31) | 6.133 (2) & 0.047 | 7.05 (2) & 0.007 | 5.58 (2) & 0.06 | 0.45 (0.23–0.85) | 0.42 (0.22–0.80) | 0.4 (0.18–0.85) |
| A/G | 74 (0.57) | 50 (0.49) | 49 (0.48) | 22 (0.46) | ||||||
| G/G | 36 (0.28) | 22 (0.22) | 24 (0.23) | 11 (0.23) | ||||||
| A | 114 (0.44) | 108 (0.54) | 111 (0.53) | 52 (0.54) | 4.21 (1) & 0.04 | 4.19 (1) & 0.04 | 3.00 (1) & 0.08 | 0.67 (0.46–0.98) | 0.68 (0.47–0.98) | 0.66 (0.41–1.05) |
| G | 146 (0.56) | 94 (0.46) | 97 (0.47) | 44 (0.46) | ||||||
| Dominant | ||||||||||
| AA | 20 (0.15) | 29 (0.28) | 31 (0.30) | 15 (0.32) | 6.041 (1) & 0.014 | 7.05 (1) & 0.007 | 5.58 (1) & 0.018 | 0.45 (0.23–0.85) | 0.42 (0.22–0.80) | 0.4 (0.18–0.85) |
| AG + GG | 110 (0.85) | 72 (0.72) | 73 (0.70) | 33 (0.68) | ||||||
| Over-dominant | ||||||||||
| AA+GG | 56 (0.44) | 51 (0.51) | 55 (0.52) | 26 (0.54) | 1.25 (1) & 0.26 | 2.22 (1) & 0.135 | 1.73 (1) & 0.18 | 0.74 (0.44–1.24) | 0.67 (0.40–1.13) | 0.64 (0.33–1.23) |
| AG | 74 (0.56) | 50 (0.49) | 49 (0.48) | 22 (0.46) | ||||||
| Recessive | ||||||||||
| AA+AG | 94 (0.72) | 79 (0.78) | 80 (0.77) | 37 (0.77) | 1.05 (1) & 0.304 | 0.64 (1) & 0.42 | 0.41 (1) & 0.52 | 0.72 (0.39–1.33) | 0.78 (0.43–1.41) | 0.77 (0.36–1.66) |
| GG | 36 (0.28) | 22 (0.22) | 24 (0.23) | 11 (0.23) | ||||||