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. 2024 Mar 12;16:14. doi: 10.1186/s13099-024-00609-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Venn diagram of significant metabolites across all six time points of TBM treatment. Number of cases according to TBM stages per time point are given in square brackets. Abbreviations: 2HGA, 2-hydroxyglutaric acid; 3HIA, 3-hydroxyisovaleric acid; 3MGA, 3-methylglutaconic acid; 4HPAA:4-hydroxyphenylacetic acid; AA, aconitic acid; EA, ethylmalonic acid; GA, glucaric acid; HG, hexanoylglycine; ICA, isocitric acid; NAAA, N-acetylaspartic acid; NAP, N-acetylphenylalanine; VA, vanillactic acid; 2HAA, 2-hydroxyadipic acid; 2HPAA, 2-hydroxyphenylacetic acid; 2KGA, 2-ketoglutaric acid; 2MBG, 2-methylbutyrylglycine; 2ODA, 2-octenedioic acid; 2,3PCA, 2,3-pyridinecarboxylic acid; 3HGA, 3-hydroxyglutaric acid; 3HPA, 3-hydroxypropionic acid; 3MCG, 3-methylcrotonylglycine; 3,4DHPAA, 3,4-dihydroxyphenylacetic acid; 4-H-3MMA, 4-hydroxy-3-methoxymandelic acid; 4HPLA, 4-hydroxyphenyllactic acid; 4HHA, 4-hydroxyhippuricacid; 5HIAA, 5-hydroxyindoleacetic acid; 5HHA, 5-hydroxyhexanoic acid; BG, buterylglycine; HA, homovanillic acid; IG, isobutyrylglycine; MCA, methylcitric acid; MSA, methylsuccinic acid; NAT, N acetyltyrosine; PAG, phenylacetylglutamine; PA, pimelic acid; SA, suberic acid; TG, tiglylglycine