TABLE 2.

A list of 11 prioritized compounds for nine VaSC OGs^a,b

Orthogroup		ChEMBL
OG No.	Expression	Functional description of the target	Compound	pchembl	QED
OG0003722	CEO in all	Ubiquitin carboxyl-terminal hydrolase	Degrasyn, WP1130	5.52	0.46
OG0007536	CEO in all	Carboxypeptidase	Anabaenopeptin B	5.27	0.07
OG0008885	CEO in all	Casein kinase II subunit beta	Digitoxigenin	8.1	0.69
OG0009146	↑ DEO in parasitic	α-crystallin B	25-Hydroxycholesterol	6.5	0.52
			Lanosterol	5.85	0.45
OG0009155	CEO in all	PKA catalytic subunit alpha	K-252a	10.8	0.37
		MAP kinase-interacting serine/threonine kinase	Staurosporine	10.7	0.41
		Calcium/calmodulin-dependent protein kinase	Calcitriol	10.6	0.52
OG0009699	CEO in all	PKA catalytic subunit alpha	K-252a	10.8	0.37
		MAP kinase-interacting serine/threonine kinase	Staurosporine	10.7	0.41
		Calcium/calmodulin-dependent protein kinase	Calcitriol	10.6	0.52
OG0009358	CEO in all	Prostaglandin reductase 1	Irofulven	7.26	0.74
OG0010069	CEO in all	Nuclear ribonucleoprotein A1	Camptothecin	7.08	0.53
OG0010756	CEO in all	15-hydroxyprostaglandin dehydrogenase	SW033291	10	0.41

^a Constitutively expressed orthogroup refers to orthogroup having a membership of constitutively expressed genes spanning all the five clade Va species in all, free-living, or parasitic stages.

^b Differentially expressed orthogroup refers to orthogroup having a membership of differentially expressed genes spanning all the five clade Va species between free-living and parasitic stages.