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. 2024 Mar 13;14(3):e081926. doi: 10.1136/bmjopen-2023-081926

Figure 1.

Figure 1

HRs of incident disease outcomes (95% CI) in selected p.C282Y/p.H63D genotypes compared with those with no mutations. HRs compared with those with neither HFE mutation. Cox proportional hazard regression models adjusted for age, assessment centre and genetic principal components 1–10. Joint replacement surgery includes a diagnosis of hip, knee, ankle or shoulder replacement. Any brain outcome included a diagnosis of delirium, dementia or Parkinson’s disease. See online supplemental eTables 4, 5, 9 and 10 for incident numbers and HRs for all p.C282Y/p.H63D genotype groups. CHD, coronary heart disease; LRTI, lower respiratory tract infection; URTI, upper respiratory tract infection; SSTI, skin and soft tissue infection; UTI, urinary tract infection.