Figure 2.

Cumulative incidence of outcomes from ages 40 to 80 years by HFE genotypes (no p.C282Y or p.H63D variants vs p.C282Y homozygotes and p.C282Y homozygotes undiagnosed with haemochromatosis at baseline). Cumulative incidence (estimated % diagnosed by age 80 years; 95% CIs) for significant outcomes (p<0.05) from Cox proportional hazard regression models (figure 1; online supplemental eTables 5, 7, 10 and 12). Joint replacement surgery includes a diagnosis of hip, knee, ankle or shoulder replacement. Any brain outcome included a diagnosis of delirium, dementia or Parkinson’s disease. SSTI, skin and soft tissue infection; UTI, urinary tract infection.