FIGURE 4.

OFT results show that neither CORT nor Reelin altered anxiety-like behavior, and few sex differences were observed. (A) Total distance traveled for female rats exposed to 1.3 cycles of CORT shows no alterations in the distance traveled in the OFT. (B) Total time in the center region of the OFT showing no alterations in rats exposed to 1.3 cycles. (C) Latency to enter the center region in rats exposed to 1.3 cycles, showing no significant alterations due to stress. (D) Total distance traveled in the OFT for rats exposed to 2.6 cycles, showing no effect of chronic stress on the distance traveled, but female rats treated with CORT traveled significantly further than males treated with CORT. (E) Total time in the center region of the OFT for rats exposed to 2.6 cycles, showing no effect of stress, but female vehicle/vehicle-treated rats spent significantly less time in the center region of the OFT compared to male vehicle/vehicle-treated rats. (F) Latency to enter the center zone for rats exposed to 2.6 cycles showing no significant effect of stress or sex differences in the latency to enter the center zone.