Figure 1.

Altered composition of the gut microbiota during IAV infection. (a), left panel, Bray Curtis based nonmetric multidimensional scaling plot of all samples (stress value = 0.09). Each spot represents one sample and each group of mice is denoted by a different color (blue: non-infected/Day 0, red: D7, orange, D14). Distance between dots represents extent of compositional difference. right panel, Bray Curtis distance among samples at D0 (reference) and between each samples at D7 or D14 and D0. (b and c), relative abundance of taxa significantly different between D7 and D0 or D14 at the phylum (b), and species (c) level. Blue represents D0 samples; red represents D7; orange represents D14. Significant differences were determined using the Kruskal-Wallis test. Significant differences were determined using the Kruskal-Wallis test (* p < 0.05, ** p < .01, *** p < .001, **** p < .0001). NMDS, non-metric multidimensional scaling plot.