Figure 2.

Functional profiles of the gut microbiota during IAV infection. (a and b), PCA of normalized relative abundances of KOs (a) and module scores (b). (c), representation at the category level of the KOs with the most varying songbird coefficients aggregated at the module level. For each module, the coefficients of the KOs taking part in it are summed up. Then, modules were grouped into categories according to larger biological functions. Each dot on the plot represents the sum of KO coefficients for a module. Red lines are medians and boxes represent Q1 and Q3. A positive coefficient means an increase of the module on D7, whereas a negative coefficient illustrates a decrease. The higher or lower the coefficient, the greater the change. Red arrows indicate increased categories and blue arrows indicate lowered categories. Asterisks denote categories decreased on D7 and increased on D14. The categories not shown have modules with KOs with null abundance (not detected) or not selected (not in the top 25% of the KOs with the most extreme coefficients).