Figure 3.

Alteration of specific metabolic compartments during influenza as assessed by shotgun analysis. (a and b), alteration of the abundance of genes involved in SCFA synthesis. (a), PCA of normalized relative abundances of modules covering SCFAs metabolism. (b), density ridgeline plots of the songbird coefficients of gomixer modules involved in SCFA synthesis and degradation. A positive coefficient is associated with an increase of the module’s KOs in D7, whereas a negative coefficient is associated with a decrease. The coefficients/differentials of the KOs computed by songbird are plotted on the x-axis (thin bars). The thick bar is the origin of the x-axis. (c–f), density ridgeline plots of the songbird coefficients of gomixer modules involved in LPS (c), fatty acid (b), polyamine (c), amino acid (arginine, proline, serine, threonine, cysteine and methionine) (d), branched- amino acid (d), branched chain amino acid (e), and aromatic amino acid (f) synthesis and degradation. A positive coefficient is associated with an increase of the module’s KOs in D7, whereas a negative coefficient is associated with a decrease. The coefficients/differentials of the KOs computed by songbird are plotted on the x-axis (thin bars). The thick bar is the origin of the x-axis.