TABLE 1.
Characteristics of study subjects
| Couplea | Ageb (yr) of:
|
Reported length of risk period (yr)c | Time of load determina- tion (mo)d | Virus phenotype at moment of (possible) transmissione | No. of virus clones analyzed | |
|---|---|---|---|---|---|---|
| NR or R | NT or T | |||||
| D1 | 26 | 28 | 3 | 6.5 | NSI | 4 |
| D2 | 41 | 43 | 13 | 5.9 | NSI | 5 |
| D3 | 43 | 46 | 4 | 8.5 | NSI | 5 |
| D4 | 24 | 38 | 3 | 2.9 | NSI | 5 |
| D5 | 45 | 53 | 4 | 3.0 | NSI | 5 |
| D6 | 33 | 33 | 7 | 12.2 | NSI | 4 |
| D7 | 34 | 41 | 2 | 6.6 | NSI | 4 |
| D8 | 33 | 40 | NK | 8.8 | NSI | 5 |
| D9 | 40 | 40 | 9 | 3.0 | NSI | 4 |
| D10 | 40 | 34 | 0.5 | 3.3 | NSI | 5 |
| C1 | 40 | 49 | 1 | 4.3 | NSI | 5 |
| C2 | 56 | 41 | 0.5 | 31.1 | NSI | 3 |
| C3 | 30 | 27 | 1 | 7.3 | NSI | 5 |
| C4 | 34 | 49 | <0.5 | 4.2 | NSI | 5 |
| C5 | 36 | 28 | NK | −3.1 | NSI | 5 |
| C6 | 37 | 34 | 1 | 21.4 | NSI | 5 |
| C7 | 44 | 30 | NK | 6.1 | SI | 5f |
| C8 | 28 | 39 | 4 | 2.7 | NSI | 5 |
| C9 | 48 | 32 | NK | 17.1 | NSI | 0 |
| C10 | 31 | 24 | 2 | 3.5 | NSI | 0 |
a
D, discordant; C, concordant.
b
Age of transmitters (T) and recipients (R) at moment of transmission and age of nontransmitters (NT) and nonrecipients (NR) at the end of the risk period.
c
In concordant couples, the period of unsafe sex until the moment of transmission. NK, not known.
d
Months after entry for nontransmitters and after the moment of seroconversion of the partner for transmitters.
e
In nontransmitters, the phenotype of the first time point at which virus clones were successfully grown; in transmitters, the phenotype close to the time point of seroconversion of the partner.
f
Two NSI and three SI variants were analyzed.