TABLE 2.

Origin and function of genes and enzymes used in this study.

Gene	Enzyme	Size (nt/aa)	Origin	CDS	Catalytic function
aknX2	AknX2	717/238	S. galilaeus	CP966_RS29165	N-methyltransferase
aclP	AclP	732/243	S. galilaeus	CP966_RS29066	N-methyltransferase
dnrS	DnrS	1,296/431	S. peucetius	CGZ69_RS24500	Glycosyltransferase
dnrQ	DnrQ	1,317/438	S. peucetius	CGZ69_RS24505	Glycosyltransferase auxiliary protein
aknS	AknS	1,332/443	S. galilaeus	CP966_RS29040	Glycosyltransferase
aknT	AknT	1,332/443	S. galilaeus	CP966_RS29045	Glycosyltransferase auxiliary protein
dnrP	DnrP	885/294	S. peucetius	CGZ69_RS24510	15-Methylesterase
rdmC	RdmC	894/297	S. purpurascens	LYO46_16725	15-Methylesterase
dnrK	DnrK	1,071/356	S. peucetius	CGZ69_RS24515	4-O-methyltransferase (10-decarboxylase moonlighting activity)
doxA	DoxA	1,248/415	S. peucetius	CGZ69_RS24600	Cytochrome P450 monooxygenase
doxA-1 a	DoxA-1	1,248/415	S. peucetius	CGZ69_RS24600	Cytochrome P450 monooxygenase
doxA-2 a	DoxA-2	1,248/415	S. bellus	GCM10010244_ 64,990	Cytochrome P450 monooxygenase
doxA-3 a	DoxA-3	1,248/415	S. coeruleorubidus	CP976_32970	Cytochrome P450 monooxygenase
drrA	DrrA	993/330	S. peucetius	CGZ69_RS24655	ABC-family transporter (ATP-binding subunit)
drrB	DrrB	852/283	S. peucetius	CGZ69_RS24650	ABC-family transporter (permease subunit)

^a Genes were codon-optimised based on the codon usage of Streptomyces coelicolor.