TABLE 2.
Buprenorphine Treatment Characteristics (n = 153)
| Variables | Value |
|---|---|
| Indication for buprenorphine, n (%) | |
| Opioid use disorder | 132 (86.3) |
| Iatrogenic opioid dependence | 10 (6.5) |
| Acute pain | 10 (6.5) |
| Central storming due to anoxic brain injury | 1 (0.7) |
| Time from ICU admission to first buprenorphine dose, median, d (IQR) | 2 (1–5) |
| Receiving buprenorphine via prescription as an outpatient, n (%)a | 75 (49) |
| Outpatient buprenorphine continued within 24 hr of ICU admission, n (%) | 46/75 (61.3) |
| Outpatient buprenorphine NOT continued within 24 hr of ICU admission, n (%) | 29/75 (38.7) |
| Reasons for delay of initiation of outpatient buprenorphine past 24 hr from admission, n (%) | |
| Held by the ICU treatment team | 24/29 (82.8) |
| Surgery | 2/29 (6.9) |
| Held by the floor team before ICU | 1/29 (3.4) |
| Refused by patient | 1/29 (3.4) |
| Team unaware of outpatient prescription | 1/29 (3.4) |
| Incidence of precipitated withdrawal with buprenorphine administration, n (%) | 1 (0.7) |
| Addiction Medicine Team consult, n (%) | 126 (82.4) |
| Final buprenorphine dose reached during induction, median mg (IQR)b | 4 (2–8) |
| Buprenorphine continued as hospital discharge for patients previously receiving buprenorphine via prescription before admission, n (%)c | 63/71 (88.7) |
| Buprenorphine continued at hospital discharge for patients receiving buprenorphine for a nonopioid use disorder indication in the ICU, n (%)c | 10/18 (55.6) |
IQR = interquartile range.
a
Five patients reported buprenorphine use without a valid prescription.
b
In the subset of patients not taking buprenorphine before admission (n = 73).
c
In those surviving hospital discharge.