Table 1. Association of genetically predicted SBP with CAD risk in the Mendelian randomization analysis.

Method	OR	95% CI	P
Note: OR>1 indicates that increased SBP was associated with an increased risk of CAD; The Cochran’s Q=589.23 ( P=2.17×10 −8), and I 2=30.24%, indicating that there was heterogeneity. The MR-PRESSO global test ( P<1×10 −4) and MR-Egger intercept test ( P=0.481) indicated that there was horizontal pleiotropy for the selected instruments. Abbreviation: CAD=coronary artery disease; CI=confidence interval; MR-PRESSO=Mendelian Randomization Pleiotropy RESidual Sum and Outlier; IVW=inverse variance weighted; OR=odds ratio; SBP=systolic blood pressure; WM=weighted median.
WM	1.03	1.02 to 1.03	2.33×10 −19
IVW	1.03	1.03 to 1.04	1.76×10 −56
MR-Egger	1.04	1.03 to 1.05	1.73×10 −11
MR-PRESSO	1.03	1.03 to 1.04	1.96×10 −44