Table S1. Description of GWAS summary-level data used in this study.
| Trait | Year | GWAS ID | Population | Sample size | Number of SNPs | Source (Pubmed ID) |
| Note: “–” means not applicable. ID means GWAS ID on the MRbase website, which is a website of large-scale public GWAS datasets; PMID, the ID number of the articles published in PubMed.
Abbreviation: SNP=single nucleotide polymorphism; GWAS=genome-wideassociation studies; CAD=coronary artery disease; BMI=body mass index; WHRadjBMI=waist-to-hip ratio adjusted for BMI; FG=fasting blood glucose; FI=fasting blood insulin; DBP=diastolic blood pressure; SBP=systolic blood pressure; IL-6=interleukin-6; CRP=C-reactive protein; TG=triglycerides; TC=total cholesterol. | ||||||
| Circulating glycine levels | 2020 | met-d-Gly | European | 114,972 | 12,321,875 | Nightingale Health Plc;
Biomarker Quantification Version 2020 |
| CAD | 2015 | ebi-a-GCST003116 | European | 141,217 | 8,597,751 | 26343387 |
| CAD | 2020 | bbj-a-159 | East Asian | 212,453 | 8,881,048 | – |
| BMI | 2018 | ieu-b-40 | European | 681,275 | 2,336,260 | 30124842 |
| WHRadjBMI | 2015 | ieu-a-79 | European | 210,082 | 210,082 | 25673412 |
| FG | 2012 | ebi-a-GCST005186 | European | 58,074 | 2,599,409 | 22581228 |
| FI | 2012 | ebi-a-GCST005185 | European | 51,750 | 2,598,774 | 22581228 |
| DBP | 2018 | ieu-b-39 | European | 757,601 | 7,160,619 | 30224653 |
| SBP | 2018 | ieu-b-38 | European | 757,601 | 7,088,083 | 30224653 |
| CRP | 2018 | ieu-b-35 | European | 204,402 | 2,414,379 | 30388399 |
| IL-6 | 2019 | prot-c-4673_13_2 | European | 1,338 | 501,428 | 28240269 |
| TG | 2013 | ebi-a-GCST002216 | European | 94,595 | 2,410,057 | 24097068 |
| TC | 2013 | ebi-a-GCST002221 | European | 94,595 | 2,418,562 | 24097068 |