Table 2:

Summary statistics of the interfaces of the benchmark dataset of homodimers. The full dataset and major properties and annotations associated with each entry can be found in the Supplementary Table S1. The calculation performed with freesasa-2.0.3 (Mitternacht 2016).

Min.	1st Qu.	Median	Mean	3rd Qu.	Max.	set	property
1	49	65	72.2	83	663	all	number of contacts*
100.62	1612.79	2097.57	2273.57	2646.31	10984.55	all	BSA
38.08	540.63	791.64	873.09	1100.79	4540.25	all	BSA polar
22.2	994.15	1260.71	1396.86	1632.15	7170.96	all	BSA apolar
0.09	0.31	0.38	0.38	0.45	0.86	all	fraction BSA polar
0.14	0.55	0.62	0.62	0.69	0.91	all	fraction BSA apolar
13	45	57	62.71	72	262	physio	number of contacts*
589.93	1421.01	1778.8	1918.41	2150.92	7202.51	physio	BSA
114.73	435.52	582.5	653.9	780.13	2721.74	physio	BSA polar
101.16	944.95	1167.95	1264.51	1458.69	4480.77	physio	BSA apolar
0.09	0.28	0.34	0.34	0.39	0.86	physio	fraction BSA polar
0.14	0.61	0.66	0.66	0.72	0.91	physio	fraction BSA apolar
1	57	72	81.63	92	663	non-physio	number of contacts*
100.62	2074.61	2426.91	2626.61	2959.75	10984.55	non-physio	BSA
38.08	796.62	1033.73	1090.98	1284.65	4540.25	non-physio	BSA polar
22.2	1091.63	1366.69	1528.42	1768.84	7170.96	non-physio	BSA apolar
0.09	0.36	0.43	0.42	0.49	0.78	non-physio	fraction BSA polar
0.22	0.51	0.57	0.57	0.63	0.91	non-physio	fraction BSA apolar

^*Residue-Residue contacts, using a distance threshold of 5 Å.