Table 2.
Prognostic value of KIF-12 in d-THCA
| Characteristics | Total (N) | HR (95% CI) Univariate analysis | P value Univariate analysis | HR (95% CI) Multivariate analysis | P value Multivariate analysis |
|---|---|---|---|---|---|
| T stage (T3&T4 vs. T1&T2) | 500 | 2.507(1.434-4.385) | 0.001 | 0.752(0.181-3.115) | 0.694 |
| N stage (N1 vs. N0) | 452 | 1.578(0.885-2.814) | 0.122 | ||
| M stage (M1 vs. M0) | 291 | 7.542(2.860-19.891) | <0.001 | 6.818(2.103-22.106) | 0.001 |
| Pathologic stage (Stage III & Stage IV vs. Stage I & Stage II) | 500 | 2.615(1.515-4.515) | <0.001 | 2.712(0.811-9.068) | 0.105 |
| Residual tumour (R1&R2 vs. R0) | 440 | 1.773(0.856-3.674) | 0.123 | ||
| Histological type (Classical vs. Follicular & Other & Tall Cell) | 502 | 1.022(0.553-1.888) | 0.944 | ||
| Age (>45 vs. <=45) | 502 | 1.618(0.924-2.834) | 0.092 | 1.109(0.370-3.323) | 0.853 |
| Sex (Male vs. Female) | 502 | 1.529(0.863-2.709) | 0.146 | ||
| Race (White vs. Asian & Black or African American) | 410 | 1.183(0.529-2.646) | 0.682 | ||
| Neoplasm location (Bilateral vs. Isthmus & Left lobe & Right lobe) | 496 | 1.150(0.558-2.370) | 0.704 | ||
| Primary neoplasm focus type (Multifocal vs. Unifocal) | 492 | 1.036(0.595-1.802) | 0.901 | ||
| Thyroid gland disorder history (Lymphocytic Thyroiditis & Nodular Hyperplasia & Other, specify vs. Normal) | 444 | 0.966(0.520-1.795) | 0.913 | ||
| Extrathyroidal extension (Yes vs. No) | 484 | 1.995(1.151-3.458) | 0.014 | 1.054(0.303-3.663) | 0.935 |
| BRAF status (Mut vs. WT) | 485 | 1.266(0.703-2.280) | 0.432 | ||
| NRAS status (Mut vs. WT) | 485 | 1.958(0.830-4.615) | 0.125 | ||
| HRAS status (Mut vs. WT) | 485 | 1.033(0.251-4.258) | 0.964 | ||
| KIF12 (High vs. Low) | 502 | 0.431(0.239-0.777) | 0.005 | 0.319(0.130-0.784) | 0.013 |