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. 2024 Feb 24;15(8):2123–2136. doi: 10.7150/jca.92633

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Transcriptome profiling analysis indicates CBX2 deletion suppressed the MAPK signalling pathway. (A) Scatterplot of differentially expressed genes of RNA-seq in CBX2 knockout HCT116 cells and control cells. (B) KEGG pathway analysis showing enriched pathways by RNA-seq. (C) GO pathway analysis showing enriched pathways by RNA-seq. (D) WB analysis showed that deletion of CBX2 decreased the phosphorylation levels of ERK and p38 MAPK. (E) The heatmap about differentially expressed genes in the MAPK pathway is present. (F) qPCR is used to confirm the results of the heatmap. Data are shown as mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001.