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. 2024 Feb 29;15:1360891. doi: 10.3389/fphys.2024.1360891

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Copyright © 2024 Yang, Ye, Deng and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Uridine and its metabolism (A). The mechanism of uridine synthesis and catabolism and the role of uridine in the hexosamine biosynthetic pathway and glycogen synthesis (B). Relationship between ATP consumption and uridine. UTP is produced by the phosphorylation of UDP with ATP used as phosphate donor, a decrease in ATP concentration results in decreased phosphorylation of UDP to UTP, leading to increased UDP and uridine-5′-monophosphate (UMP). These changes accelerate the degradation of uracil nucleotides (UTP→UDP→UMP→ uridine). G-6-P: glucose-6-phosphate; F-6-P: fructose-6-phosphate; GlcN:glucosamine; GlcNAc:N-acetyl glucosamine; UDP:uridine-5′-diphosphate; UTP:uridine-5′-triphosphate; PPi:inorganic pyrophosphate; ADP:cytidine -5′-diphosphate; ATP:cytidine -5′-triphosphate.