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. 2024 Mar 1;56(3):395–407. doi: 10.1038/s41588-023-01651-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a–f, Lateral view of Alexa Fluor phalloidin filamentous actin (green) and α-actinin Z-band marker (red) staining in skeletal fast muscle fibers in wild-type (a,d), srpk3^+/+;ttn.1^−/− (b,e) and srpk3^−/−;ttn.1^−/− (c,f) larvae at 5 dpf. Compared to wild-type fish (a,d), the muscle fiber structure was largely lost in the ttn.1-null zebrafish, regardless of the srpk3 status (that is both srpk3^+/+;ttn.1^−/− and srpk3^−/−;ttn.1^−/−). Scale bars are 25 µm. Representative images from >15 pooled fish per genotype.