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. 2024 Jan 30;56(3):383–394. doi: 10.1038/s41588-024-01653-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Heatmaps depict log₂-transformed relative expression in each cell type, calculated based on the mean of DESeq2-normalized counts from 7-8 control donors. Genes identified as HD age at onset-modifying candidates are marked with an asterisk. Genes known to influence CAG tract instability in HD mouse models are marked with an arrowhead. b-d, Relative levels of MSH2 (b), MSH3 (c) and FAN1 (d) transcripts in MSNs compared to interneurons, calculated with DESeq2 using cell type-specific FANS-seq data from control donors. The largest P adj. value of all MSN vs. interneuron comparisons (by DESeq2, P adjusted for multiple comparisons) is indicated for each gene. For caudate nucleus samples: n = 8 individuals for dMSNs, iMSNs, TAC3 + IN, PVALB + IN and SST + IN. For putamen samples: n = 8 individuals for dMSNs, iMSNs, TAC3 + IN, n = 7 individuals for PVALB + IN and n = 6 individuals for SST + IN.