Figure 5.

NOD.Ifih1^R increases the frequency of IFN-γ⁺CD8⁺ central memory and effector memory T cells in non-draining lymph nodes (LN). (A) Representative gating of CD8⁺ Naïve (CD62L⁺), central memory (CD62L⁺CD44⁺, T_CM), effector memory (CD62L^-CD44⁺, T_EM), and IFN-γ⁺CD8⁺ central memory and effector memory T cells from PMA/ionomycin-treated non-draining lymph nodes. (B, C) The frequency of IFN-γ⁺ CD8⁺ central memory and effector memory T cells from PMA/ionomycin-treated non-draining lymph nodes from (B) all mice (n=8 NOD.Ifih1^NR/NR , n=10 NOD.Ifih1^R/R ) and (C) females only (n=6 NOD.Ifih1^NR/NR , n=7 NOD.Ifih1^R/R). P values were determined using student’s unpaired t tests. All data are mean ± SEM.